Tip-Enhanced Raman Spectroscopy
TERS works in conjunction with scanning probe microscopy (SPM), a technique that utilizes a metal tip to probe the size and shape of samples at atomic dimensions.
The tip can be coated with silver or gold and, when brought close to a sample of molecules, excited with a laser yielding a spectra with greatly enhanced Raman signal.
TERS confines the signal enhancement to the near-field surrounding the very sharp SPM tip, allowing optical spatial resolution down to ~ 10 nm. The signal can be so strong that single molecules can be detected, ideal for samples that exhibit heterogeneities on the nanoscale.
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Application Note